Blar i forfatter "Fasanelli, Francesca"

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    • Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study 

      Baumeister, Sebastian E.; Schlesinger, Sabrina; Aleksandrova, Krasimira; Jochem, Carmen; Jenab, Mazda; Gunter, Marc J.; Overvad, Kim; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Fournier, Agnès; Kühn, Tilman; Kaaks, Rudolf; Pischon, Tobias; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; La Vecchia, Carlo; Masala, Giovanna; Panico, Salvatore; Fasanelli, Francesca; Tumino, Rosario; Grioni, Sara; Bueno-de-Mesquita, Hendrik Bastiaan; Vermeulen, Roel; May, Anne M.; Borch, Kristin Benjaminsen; Oyeyemi, Sunday Oluwafemi; Ardanaz, Eva; Rodríguez-Barranco, Miguel; Chirlaque López, María Dolores; Felez-Nobrega, Mireia; Sonestedt, Emily; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Mårten; Perez-Cornago, Aurora; Ferrari, Pietro; Stepien, Magdalena; Freisling, Heinz; Tsilidis, Konstantinos K.; Ward, Heather; Riboli, Elio; Weiderpass, Elisabete; Leitzmann, Michael F. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-22)
      <i>Background & Aims</i> - To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).<p><p> <i>Methods</i> - We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder ...

    • Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study 

      Perrier, Flavie; Viallon, Vivian; Ambatipudi, Srikant; Ghantous, Akram; Cuenin, Cyrille; Hernandez-Vargas, Hector; Chajès, Véronique; Baglietto, Laura; Matejcic, Marco; Moreno-Macías, Hortensia; Kühn, Tilman; Boeing, Heiner; Karakatsani, Anna; Kotanidou, Anastasia; Trichopoulou, Antonia; Sieri, Sabina; Panico, Salvatore; Fasanelli, Francesca; Dollé, Martijn; Onland-Moret, Charlotte; Sluijs, Ivonne; Weiderpass, Elisabete; Quirós, José Ramón; Agudo, Antonio; Huerta, José María; Ardanaz, Eva; Dorronsoro, Miren; Tong, Tammy Y.N.; Tsilidis, Konstantinos K.; Riboli, Elio; Gunter, Mark J.; Herceg, Zdenko; Ferrari, Pietro; Romieu, Isabelle (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-02)
      <i>Background</i> - There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We investigated the association of dietary folate and alcohol intake on leukocyte DNA methylation levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) ...

    • Diet quality scores and prediction of all-cause, cardiovascular and cancer mortality in a pan-european cohort study 

      Lassale, Camille; Gunter, Marc J.; Romaguera, Dora; Peelen, Linda M.; van der Schouw, Yvonne T.; Beulens, Joline W.J.; Freisling, Heinz; Muller, David C.; Ferrari, Pietro; Huybrechts, Inge; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Affret, Aurélie; Overvad, Kim; Dahm, Christina C.; Olsen, Anja; Roswall, Nina; Tsilidis, Konstantinos K.; Katzke, Verena A.; Kühn, Tilman; Buijsse, Brian; Quirós, José Ramón; Sánchez-Cantalejo, Emilio; Etxezarreta, Nerea; Huerta, José María; Barricarte, Aurelio; Bonet, Catalina; Khaw, Kay-Tee; Key, Timothy J.; Trichopoulou, Antonia; Bamia, Christina; Lagiou, Pagona; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Boer, Jolanda M.A.; Sonestedt, Emily; Nilsson, Lena Maria; Renström, Frida; Weiderpass, Elisabete; Skeie, Guri; Lund, Eiliv; Moons, Karel G.M.; Riboli, Elio; Tzoulaki, Ioanna (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-13)
      Scores of overall diet quality have received increasing attention in relation to disease aetiol- ogy; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective ...

    • Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort 

      Zamora-Ros, Raul; Barupal, Dinesh Kumar; Rothwell, Joseph A.; Jenab, Mazda; Fedirko, Veronika; Romieu, Isabelle; Aleksandrova, Krasimira; Overvad, Kim; Kyrø, Cecilie; Tjønneland, Anne; Affret, Aurélie; His, Mathilde; Boutron-Ruault, Marie-Christine; Katzke, Verena; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Naska, Androniki; Kritikou, Maria; Saieva, Calogero; Agnoli, Claudia; Santucci de Magistris, Maria; Tumino, Rosario; Fasanelli, Francesca; Weiderpass, Elisabete; Skeie, Guri; Merino, Susana; Jakszyn, Paula; Sánchez, María-José; Dorronsoro, Miren; Navarro, Carmen; Ardanaz, Eva; Sonestedt, Emily; Ericson, Ulrika; Maria Nilsson, Lena; Bodén, Stina; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Perez-Cornago, Aurora; Wareham, Nicholas J.; Khaw, Kay-Thee; Freisling, Heinz; Cross, Amanda J.; Riboli, Elio; Scalbert, Augustin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-22)
      Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of ...

    • DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk 

      Baglietto, Laura; Ponzi, Erica; Haycock, Philip; Hodge, Allison; Bianca Assumma, Manuela; Jung, Chol-Hee; Chung, Jessica; Fasanelli, Francesca; Guida, Florence; Campanella, Gianluca; Chadeau-Hyam, Marc; Grankvist, Kjell; Johansson, Mikael; Ala, Ugo; Provero, Paolo; Wong, Ee Ming; Joo, Jihoon; English, Dallas R.; Kazmi, Nabila; Lund, Eiliv; Faltus, Christian; Risch, Angela; Barrdahl, Myrto; Sandanger, Torkjel M; Southey, Melissa C.; Giles, Graham G.; Johansson, Mattias; Vineis, Paolo; Polidoro, Silvia; Relton, Caroline L.; Severi, Gianluca (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-15)
      DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether methylation in DNA from pre‐diagnostic, peripheral blood samples is associated with lung cancer risk. We used a case‐control study nested within the EPIC‐Italy cohort and a study within the MCCS cohort as discovery sets (a total of 552 case‐control pairs). We ...

    • Hepcidin levels and gastric cancer risk in the EPIC-EurGast study 

      Jakszyn, Paula; Fonseca-Nunes, Ana; Lujan-Barroso, Leila; Aranda, Núria; Tous, Monica; Arija, Victoria; Cross, Amanda; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Kühn, Tilman; Kaaks, Rudolf; Sjöberg, Klas; Tumino, Rosario; Palli, Domenico; Ricceri, Fulvio; Fasanelli, Francesca; Krogh, Vittorio; Mattiello, Amalia; Jenab, Mazda; Gunter, Marc; Perez-Cornago, Aurora; Khaw, Kay-Tee; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Trichopoulou, Antonia; Peppa, Eleni; Vasilopoulou, Effie; Boeing, Heiner; Sánchez-Cantalejo, Emilio; Dorronsoro, Miren; Barricarte, Aurelio; Quiros, Jose Maria; Peeters, Petra H; Agudo, Antonio (Journal article; Tidsskriftartikkel, 2017-06-21)
      Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study ...

    • Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: A multinational cohort study 

      Murphy, Neil; Ward, Heather A.; Jenab, Mazda; Rothwell, Joseph A.; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Kvaskoff, Marina; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Weiderpass, Elisabete; Skeie, Guri; Borch, Kristin Benjaminsen; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Dahm, Christina C.; Jakszyn, Paula; Sánchez, María-José; Gil, Leire; Huerta, José María; Barricarte, Aurelio; Quirós, José Ramón; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn E.; Trichopoulou, Antonia; La Vecchia, Carlo; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno-de-Mesquita, Hendrik Bastiaan; Peeters, Petra H.M.; Gylling, Björn; Myte, Robin; Jirström, Karin; Berntsson, Jonna; Xue, Xiaonan; Riboli, Elio; Cross, Amanda J.; Gunter, Mark J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)
      <i>Background & Aims</i> - Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision.<p><p> <i>Methods</i> - In the European Prospective Investigation ...

    • Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts 

      Fasanelli, Francesca; Baglietto, Laura; Ponzi, Erica; Guida, Florence; Campanella, Gianluca; Johansson, Mattias; Grankvist, Kjell; Johansson, Mikael; Assumma, Manuela Bianca; Naccarati, Alessio; Chadeau-Hyam, Marc; Ala, Ugo; Faltus, Christian; Kaaks, Rudolf; Risch, Angela; De Stavola, Bianca; Hodge, Allison; Giles, Graham G.; Southey, Melissa C.; Relton, Caroline L.; Haycock, Philip C.; Lund, Eiliv; Polidoro, Silvia; Sandanger, Torkjel M; Severi, Gianluca; Vineis, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-15)
      DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, ...